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Development of new dental implants with anti-bactericidal properties to avoid peri-implantitis
Accronym

BACTDENT

Project ID

 

IPT-2012-0218-090000

Total Budget

 

1.019.614 euros

Period

 

2012-2015

Funding agency

 

Spanish Ministry of Economy and Competitiveness and the ERDF

(INNPACTO - PNIDI 2008-2011)

Project Partners

 

 

Project Objective

The aim of this R&D project is the development of new sol-gel coatings for dental implants with antibactericidal properties to prevent peri-implantitis.

Project Justification

The use of implants has modernized dental rehabilitation and prosthetic dentistry being applied nowadays as a common treatment.

Supportive treatments and maintenance of implants comprises the basic concerns of peri-implant tissues, identification and reduction of risk factors of peri-implant mucositis and peri-implantitis are still of great relevance.

 

It has been hypothesized that when left untreated, peri-implantitis can result in implant failure. This pathology is associated with inflammation of the peri-implant mucosa caused by the formation of an adherent layer of biofilm on the surface of the implant. Reduction of the bacterial load and removal of the biofilm is essential to prevent the peri-implatitis.

 

Most of the treatments applied nowadays to treat peri-implantitis are a combination of surgical mechanical cleaning and local antimicrobials treatments.

 

The idea of covering implants surface with an anti-bactericidal coating that at the same time can be used to incorporate drugs leads to a good strategy to prevent peri-implantitis.

Scientific approach

In the sol-gel process, an alkoxide undergoes hydrolysis in the presence of water with an acid or basic catalyst, and the silanols produced condense forming a SiO2 network. Using metal alkoxides with organic chains, it is possible to obtain organic-inorganic coatings to cover metal surfaces. The last decade has seen a revolution in the area of sol-gel derived materials that have proved to be a good way to improve biocompatibility, bioactivity and bone conductivity of the metallic surfaces of the implants, and that can also be used to encapsulate biological species such as enzymes, antibodies and antibactericidal elements in a functional state.  Our approach is based on:

· Metal alkoxides used as metalorganic sol-gel precursors with different chemical characteristics to immobilize the biomolecules by physical adsorption, covalent binding, entrapment or microencapsulation

· Biological species with different grade of complexity to better characterize the coating behavior to immobilization and deliver

 
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